Mitochondrial Ion Channels in Cancer Transformation

Authors

Stephen M. Madamba, CUNY Bernard M Baruch College
Kevin N. Damri, CUNY Bernard M Baruch College
Laurent M. Dejean, California State University Fresno
Pablo M. Peixoto, CUNY Bernard M Baruch CollegeFollow

Document Type

Article

Publication Date

June 2015

Abstract

Cancer transformation involves reprograming of mitochondrial function to avert cell death mechanisms, monopolize energy metabolism, accelerate mitotic proliferation, and promote metastasis. Mitochondrial ion channels have emerged as promising therapeutic targets because of their connection to metabolic and apoptotic functions. This mini review discusses how mitochondrial channels may be associated with cancer transformation and expands on the possible involvement of mitochondrial protein import complexes in pathophysiological process.

Comments

This work was originally published in Frontiers in Oncology, available at doi:10.3389/fonc.2015.00120