Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

Authors

Nadinath B. Nillegoda, Mount Sinai School of Medicine
Maria A. Theodoraki, CUNY City College
Atin K. Mandal, CUNY City College
Katie J. Mayo, University of North Carolina, Chapel Hill
Hong Yu Ren, University of North Carolina, Chapel Hill
Rasheda Sultana, CUNY City College
Kenneth Wu, Mount Sinai School of Medicine
Jill Johnson, University of Idaho
Douglas M. Cyr, University of North Carolina, Chapel Hill
Avrom J. Caplan, CUNY City College

Document Type

Article

Publication Date

July 2010

Abstract

Ubr1 and Ubr2 ubiquitin ligases are shown to promote degradation of misfolded cytosolic polypeptides in vivo and in a purified system in association with Hsp70.

Comments

This work was originally published in Molecular Biology of the Cell, available at doi:10.1091/mbc.E10-02-0098.