Date of Award

Fall 8-28-2016

Document Type

Thesis

Degree Name

Master of Arts (MA)

Departments/Programs

Chemistry

First Advisor

Dr. Wayne W. Harding

Second Advisor

Dr. Shenping Zhang

Academic Program Adviser

Dr. Yujia Xu

Abstract

(+)-Boldine, an aporphine alkaloid, is reported to be biologically active at various Central Nervous System(CNS) receptors. However, only a few Structure Activity Relationship(SAR) studies have been conducted using boldine’s aporphine scaffold. A library of novel analogs was synthesized from boldine to understand the effect of bisbenzylation at C2 and C9 positions on the affinity and selectivity at the serotonin receptors.

 
 

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