Document Type
Article
Publication Date
2023
Abstract
Microglia are a resident innate immune cell population of the central nervous system (CNS) derived from yolk sac erythro-myeloid progenitors that migrate to the developing brain prior to the formation of the blood-brain barrier. This critical cell population has gained considerable traction in the literature as it is considered a protective barrier from CNS damage and, yet, can also serve as a primary mediator of neuroinflammation. Under normal physiological conditions, microglia perform homeostatic functions, such as parenchymal surveillance, neurotrophic support, pathogen or debris removal, and maintenance of synaptic homeostasis and neuronal plasticity.
Comments
This editorial was originally published in Frontiers in Immunology, available at https://doi.org/10.3389/fimmu.2023.1227095
This work is published under a Creative Commons Attribution-NonCommercial 4.0 International License.