Publications and Research


Clifford J. Unkefer, Los Alamos National Laboratory
Richard T. Sayre, Los Alamos National Laboratory
Jon K. Magnuson, Pacific Northwest National Laboratory
Daniel B. Anderson, Pacific Northwest National Laboratory
Ivan Baxter, USDA at Donald Danforth Plant Science Center
Ian K. Balby, University of California, Los Angeles
Judith K. Brown, University of Arizona
Michael Carleton, Matrix Genetics, LLC
Rose Ann Cattolico, University of Washington
Taraka Dale, Los Alamos National Laboratory
Timothy P. Devarenne, Texas A & M University
C. Meghan Downes, New Mexico State University
Susan K. Dutcher, Washington University in St. Louis
David T. Fox, Los Alamos National Laboratory
Ursula Goodenough, Washington University in St. Louis
Jan Jaworski, Donald Danforth Plant Science Center
Jonathan E. Holladay, Pacific Northwest National Laboratory
David M. Kramer, Michigan State University
Andrew T. Koppisch, Los Alamos National Laboratory
Mary S. Lipton, Pacific Northwest National Laboratory
Babetta L. Marrone, Los Alamos National Laboratory
Margaret McCormick, Matrix Genetics, LLC
István Molnár, University of Arizona
John B. Mott, Los Alamos National Laboratory
Kimberly L. Ogden, University of Arizona
Ellen A. Panisko, Pacific Northwest National Laboratory
Matteo Pellegrini, University of California, Los Angeles
Juergen Polle, CUNY Brooklyn CollegeFollow
James W. Richardson, Texas A & M University - College Station
Martin Sabarsky, Cellana, Inc
Shawn R. Starkenburg, Los Alamos National Laboratory
Gary D. Stormo, Washington University in St. Louis
Munehiro Teshima, Los Alamos National Laboratory
Scott N. Twary, Los Alamos National Laboratory
Pat J. Unkefer, Los Alamos National Laboratory
Joshua S. Yuan, Texas A & M University
José A. Olivares, Los Alamos National Laboratory

Document Type


Publication Date



In 2010,when the National Alliance for Advanced Biofuels and Bioproducts (NAABB) consortiumbegan, littlewas known about themolecular basis of algal biomass or oil production. Very fewalgal genome sequenceswere available and efforts to identify the best-producing wild species through bioprospecting approaches had largely stalled after the U.S. Department of Energy's Aquatic Species Program. This lack of knowledge included how reduced carbon was partitioned into storage products like triglycerides or starch and the role played bymetabolite remodeling in the accumulation of energy-dense storage products. Furthermore, genetic transformation and metabolic engineering approaches to improve algal biomass and oil yields were in their infancy. Genome sequencing and transcriptional profiling were becoming less expensive, however; and the tools to annotate gene expression profiles under various growth and engineered conditions were just starting to be developed for algae. It was in this context that an integrated algal biology program was introduced in the NAABB to address the greatest constraints limiting algal biomass yield. This review describes the NAABB algal biology program, including hypotheses, research objectives, and strategies to move algal biology research into the twenty-first century and to realize the greatest potential of algae biomass systems to produce biofuels.


This article was originally published in Algal Research, available at DOI: 10.1016/j.algal.2016.06.002.

This is an open access article under the CC BY-NC-ND license (



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.