Dissertations and Theses

Date of Award


Document Type



Biomedical Engineering

First Advisor

Ali Sadegh


TBI, Concussion, SEM, Finite Element Modeling, CSF


Traumatic brain injury (TBI) is an intracranial injury caused by direct contact or non-contact head impacts to the brain. TBI is a major problem that accounts for high incidents of hospitalizations each year. Thus, it is important to understand and predict the occurrence of TBI in an impact. It has been shown that the subarachnoid space (SAS) trabeculae play an important role in damping the effect of an impact, thus reducing the injuries. However, the influence of sulci parameters and the sulci trabeculae in TBI due to impact is unexplored. Studies have shown that inclusion of sulci in brain models alters the strain in the brain, however, those models do not take into account the trabecular tissue present in the sulci.

In this study, the morphology and architecture of the sulci trabeculae in different regions of the brain was explored. It was revealed that the sulci trabeculae architecture differs from the SAS trabeculae to some extent, and the morphology varies even between different lobes of the brain. The sulci trabeculae have complex morphology with pillar, rods, tree-shapes plates and veil-like structures. In addition, through detailed 3D global and local FE modeling and analyses it was revealed that changes in the depth of the sulci changes the strain distribution in the brain during an impact. It was revealed that with increasing depth, the strain decreases along the sulci.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.