Date of Award

Spring 6-2022

Document Type


Degree Name

Master of Science (MS)


Forensic Science



First Advisor or Mentor

Richard Stripp

Second Reader

Damon Borg

Third Advisor

Teeshavi Acosta


In recent years, the use of antipsychotic medications has rapidly increased. Most of these medications have a high risk potential. Due to this risk potential, patients who are prescribed these medications have to be monitored. Therapeutic drug monitoring (TDM) has become extremely important in the clinical environment. Physicians rely on TDM to make sure patients are adhering to their prescription and to make decisions about whether the medication is working. Clozapine is a very popular antipsychotic used in the treatment of schizophrenia. The current method for TDM for clozapine is a blood test. This causes challenges for physicians, who need to perform frequent TDM tests, because collecting blood samples is an invasive procedure. This study focused to validate a method for detecting clozapine in oral fluid using a KIMS Assay. This method allows for a non-invasive sample collection and presents rapid and accurate results. This method passed multiple validation tests, including linearity, accuracy and precision, carryover potential, interfering substances, and the evaluation of authentic positive and negative samples. The linearity had a limit of quantification (LOQ) range between 50 ng/ml and 1,000 ng/ml. The imprecision was


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