Hydrogels are networked polymers with hydrophilicity that helps them to retain an ample amount of water. Recent research on hydrogels have been focusing on their use as tissue scaffolding, wound dressings, and drug delivery agents. Polydopamine is formed from the oxidation of dopamine and is attractive as a biomaterial because of the adhesive properties it imparts due to the catechol motif. We proposed polydopamine may behave utility as an antioxidant, as its precursor dopamine has antioxidant properties. We recently developed a method of preparing polysaccharide-polyamine hybrid hydrogels by first reacting the less reactive polysaccharides with the cross-linker epichlorohydrin and completed by the addition of polyamines. Here in we have expanded this methodology to utilize polydopamine as the polyamine. We successfully prepared hydrogels with 10:1, 4:1 and 2:1 dextran:dopamine mass ratios. Using electrostatic crosslinks we also prepared hydrogels from dextran sulfate and polyethyleneimine (PEI) modified with polydopamine, synthesizing 1:1 and a 2:1 PEI:dextran mass ratio hydrogels.
Syed, Abdulhaq; Dermendzhieva, Elena; Hicks, Josiah; Wong, Madeline; and O'Connor, Naphtali, "POLYDOPAMINE AS A BIOMATERIAL FOR HYDROGELS" (2019). CUNY Academic Works.