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The purpose of this research is to perform a meta-analysis on inflammation, fracture and bone repair mechanisms in the presence of surgical implants as practiced by tissue engineering and materials science today. Inflammation is the human body's natural response to an injury that activates the immune system and sends out inflammatory cells. The result is usually pain, swelling, bruising or redness. Inflammation also affects our body and often difficult to detect by routine diagnostic imaging. An X-ray exam, often followed by CT, can map the nature and extent of the fracture and help guide surgery for internal fixation of orthopedic devices implanted into the affected tissue or joint. When metal is introduced as part of the implant, an oxide layer is formed, and metal ions slowly diffuse through the oxide layer and accumulate in the tissue. The implant then becomes surrounded by a layer of fibrous tissue of thickness that is proportional to the amount and toxicity of the dissolution products and to the diffusion rate of metal ions in the adjacent tissues. Our work reviews various advancements in the interfacial interactions of surgical implants that have led to reduced inflammation in patients with metallic implants. We also demonstrate the relative efficacy of Gadolinium which normally is not a common CT agent showing equivalent opacity compared to iodine, the common CT agent.


This poster was presented at the 35th Semi-Annual Dr. Janet Liou-Mark Honors & Undergraduate Research Poster Presentation, Dec. 2, 2021. Mentor: Prof. Subhendra Sarkar (Radiologic Technology).