Health-related quality of life in COVID-19 patients: a systematic review and meta-analysis of EQ-5D studies

Authors

• Kidu Gidey, Mekelle University
• Yirga Legesse Niriayo, Mekelle University
• Solomon Weldegebreal Asgedom, Mekelle University
• Erica I. Lubetkin, CUNY School of MedicineFollow

Document Type

Article

Publication Date

10-2025

Abstract

Background

COVID-19 has affected millions globally, with a significant proportion experiencing long-COVID and impaired health-related quality of life (HRQoL). This systematic review and meta-analysis aimed to synthesize the existing literature on HRQoL in COVID-19 patients.

Methods

We conducted a systematic search of PubMed, Embase, Web of Science, Scopus, and the Cochrane Library for studies published between December 2019 and March 2025. Eligible studies were peer-reviewed and assessed HRQoL in COVID-19 patients using the EQ-5D instrument. Study quality and risk of bias were evaluated using the Newcastle-Ottawa Scale. Pooled health utility values were estimated using a random-effects model, and heterogeneity was assessed via I² statistics. Predictors of poor HRQoL were qualitatively narrated.

Results

Out of 3539 references, 187 studies with 116,525 participants were analyzed. The majority (80.2%) used the EQ-5D-5 L version. The pooled mean EQ-5D utility score was 0.76 (95% CI 0.74–0.79, I² = 99.9%) while the mean EQ-5D Visual Analogue Scale (VAS) score was 70.76 (95% CI 68.48–73.04; I² = 99.7%). Pain/discomfort and anxiety/depression were the most affected domains, reported by 51% and 46% of patients, respectively. Subgroup analysis showed significant differences in HRQoL based on national income status (p = 0.038) and geographic region (p <  0.001). Common predictors of lower HRQoL included older age, female gender, disease severity, comorbidities, and post-COVID-19 symptoms.

Conclusion

This systematic review demonstrates a substantial reduction in HRQoL among COVID-19 patients compared to the general population. The pooled utility values of COVID-19 contribute to understanding patients’ HRQoL and can assist in calculating Quality-Adjusted Life Years. This provides essential data for future economic evaluations and informs health policy decisions.

Comments

This article was originally published in Health and Quality of Life Outcomes, available at https://doi.org/10.1186/s12955-025-02421-8 

Recommended Citation

Gidey, Kidu; Niriayo, Yirga Legesse; Asgedom, Solomon Weldegebreal; and Lubetkin, Erica I., "Health-related quality of life in COVID-19 patients: a systematic review and meta-analysis of EQ-5D studies" (2025). CUNY Academic Works.
https://academicworks.cuny.edu/cm_pubs/8