Design and Application of Matrix Metalloproteinase-9-Responsive Peptide Nanostructures

Author

Jiye Son, The Graduate Center, City University of New YorkFollow

Date of Degree

5-2019

Document Type

Dissertation

Degree Name

Ph.D.

Program

Chemistry

Advisor

María Contel

Advisor

Rein V. Ulijn

Committee Members

Daniel Heller

Guillermo Gerona-Navarro

Subject Categories

Biotechnology

Keywords

Supramolecular chemistry, self-assembly, MMP, drug delivery, nanomedicine, enzyme-responsive

Abstract

Matrix metalloproteinase (MMP)-responsive materials have been investigated since the late 1990’s as scaffolds for tissue engineering and since then, have evolved into sophisticated nanomaterials for cancer-targeting therapy. In this thesis titled, “Design and Application of Matrix Metalloproteinase-9-Responsive Peptide Nanostructures,” we aim to answer the following key questions: can MMP-responsive nanomaterials improve the efficacy of anti-cancer treatments? How can we achieve specificity towards MMPs using nanomaterials? Finally, what are the advantages in using peptides as building blocks to create MMP-responsive nanostructures? Each chapter in the thesis will address one or more of the key questions and draw conclusions at the end.

Recommended Citation

Son, Jiye, "Design and Application of Matrix Metalloproteinase-9-Responsive Peptide Nanostructures" (2019). CUNY Academic Works.
https://academicworks.cuny.edu/gc_etds/3224