Pipecolic Acid and Novel Insights Into Cerebral Malaria

Author

Akua E. Mensah, CUNY Lehman CollegeFollow

Date of Award

Spring 5-1-2024

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biological Sciences

First Advisor

Johanna Daily, MD, MS

Second Advisor

Kristina Ames, PhD

Third Advisor

Stephen Redenti, PhD

Fourth Advisor

Julio Gallego-Delgado, PhD

Abstract

Cerebral malaria (CM), a severe manifestation of Plasmodium infection, prompts our investigation into the nuanced role of pipecolic acid in its pathophysiology. To unravel the molecular intricacies, we conducted in vitro lysine labeling techniques of mice infected with P. berghei ANKA parasites, and human P. falciparum grown in vitro, aiming to discern the impact of Plasmodium on pipecolic acid production. Previous observations indicated an elevation in pipecolic acid levels correlating with neurological decline in children with CM. In our study, confirming elevated pipecolic acid presence in the plasma and brain tissues of CM patients and the animal model of CM, we extend our understanding by demonstrating, the direct involvement of Plasmodium parasites in pipecolic acid production. This revelation not only highlights the relationship between Plasmodium and pipecolic acid but also shows the potential significance of targeting this pathway for therapeutic interventions in CM. By deciphering the role of Plasmodium in pipecolic acid synthesis, our research contributes valuable insights that may pave the way for innovative treatment strategies, addressing a critical gap in the understanding of CM pathogenesis

Recommended Citation

Mensah, Akua E., "Pipecolic Acid and Novel Insights Into Cerebral Malaria" (2024). CUNY Academic Works.
https://academicworks.cuny.edu/le_etds/38