Date of Award
Ali M. Sadegh
Intra cerebral Hematoma, Lateral Ventricles, Hematoma Progression, Intra Cranial Pressure, Intraventricular Hemorrhage
Cerebrovascular diseases like intra cerebral hemorrhage are quite deadly and may disturb functioning of the brain, expanding and resulting in formation of an intra cerebral hematoma(ICH). It is imperative to comprehend how hematoma and its expansion inside the brain endangers human life. One of the influences of an ICH inside brain tissue is on the Lateral Ventricles(LV). When the hemorrhage occurs close enough to the lateral ventricles, filled with cerebrospinal fluid(CSF), it disrupts the balance of fluid in LV. A minor pressure change in LV can negatively influence the production of CSF as well as an increase in intracranial pressure. This Investigation uses numerical simulations to determine the nature of these influences on lateral ventricles. Here, the analysis looks at four different volumes of ICH where the distance between the hematoma and lateral ventricles are varied between 8mm, 12mm and 16mm. In addition, the perpendicular progression of hematoma towards the lateral ventricles at 1mm, 2mm and 3mm is also an independent determinant. The results are classified on the basis of effective stresses and effective plastic strains, maximum strain in ventricles and Intra cranial pressure measured in the different regions of brain as a result of the progression. The outcomes determined that the size of ICH, its distance relative to the lateral ventricles and progression towards them, might set the foundation of ventricular diseases. Lastly, the mechanism with which an Intra Cerebral Hemorrhage induces an Intraventricular Hemorrhage (IVH) and hydrocephalus is discussed in detail with reference to the findings of this analysis.
Ashraf, Muhammad J., "The influence of size and progression of Intra-cerebral Hematoma on the Lateral Ventricles" (2019). CUNY Academic Works.