Date of Degree

5-2018

Document Type

Dissertation

Degree Name

Ph.D.

Program

Biology

Advisor

Anuradha Janakiraman

Committee Members

David Jeruzalmi

Shireen Saleque

Andrew Darwin

Lars Dietrich

Anuradha Janakiraman

Subject Categories

Bacteriology | Biochemistry | Biology | Biophysics | Cell Biology | Cellular and Molecular Physiology | Genetics | Microbial Physiology | Molecular Biology | Molecular Genetics | Organismal Biological Physiology | Structural Biology

Keywords

cytokinesis, division, FtsZ, E. coli, microbiology, genetics

Abstract

Escherichia coli is a well-known pathogen, and importantly, a widely used model organism in all fields of biological sciences for cloning, protein purification, and as a model for Gram-negative bacterial species. And yet, researchers do not fully understand how this bacterium replicates and divides. Every year additional division proteins are discovered, which adds complexity to how we understand E. coli undergoes cell division. Due to their specific roles in cytokinesis, some of these proteins may be potential targets for development of antibacterials or bacteriostatics, which are much needed for fighting the current global antibacterial deficit. My thesis work focuses on understanding how E. coli cell division is regulated.

This work is embargoed and will be available for download on Saturday, May 30, 2020

Graduate Center users:
To read this work, log in to your GC ILL account and place a thesis request.

Non-GC Users:
See the GC’s lending policies to learn more.

Share

COinS