Date of Degree

5-2019

Document Type

Dissertation

Degree Name

Ph.D.

Program

Chemistry

Advisor

María Contel

Advisor

Rein V. Ulijn

Committee Members

Daniel Heller

Guillermo Gerona-Navarro

Subject Categories

Biotechnology

Keywords

Supramolecular chemistry, self-assembly, MMP, drug delivery, nanomedicine, enzyme-responsive

Abstract

Matrix metalloproteinase (MMP)-responsive materials have been investigated since the late 1990’s as scaffolds for tissue engineering and since then, have evolved into sophisticated nanomaterials for cancer-targeting therapy. In this thesis titled, “Design and Application of Matrix Metalloproteinase-9-Responsive Peptide Nanostructures,” we aim to answer the following key questions: can MMP-responsive nanomaterials improve the efficacy of anti-cancer treatments? How can we achieve specificity towards MMPs using nanomaterials? Finally, what are the advantages in using peptides as building blocks to create MMP-responsive nanostructures? Each chapter in the thesis will address one or more of the key questions and draw conclusions at the end.

Included in

Biotechnology Commons

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