Date of Degree


Document Type

Capstone Project

Degree Name





Carol A. Silverman

Subject Categories

Speech Pathology and Audiology


N-acetylcysteine, cisplatin, ototoxicity, otoprotection, sensorineural hearing loss


Objective: The purpose of this investigation is to perform a systematic review of the existing literature on NAC efficacy in prevention of cisplatin-induced ototoxicity.

Methods: A comprehensive search utilizing databases via the Mina Rees Library of the Graduate Center of the City University of New York was conducted to identify relevant studies for analysis. The levels of evidence were applied to restrict articles reviewed to Level 3 or better.

Results: Eight articles evaluating NAC protective efficacy against cisplatin-induced ototoxicity were identified. The results revealed significant variability in NAC otoprotective efficacy.

Discussion: The significant variability in findings on NAC otoprotective efficacy may reflect lack of uniformity in the study methodologies and the limited number of clinical trials. Randomized clinical trials are needed on NAC otoprotective efficacy.

Conclusions: The findings of the reviewed studies show promise in preventing otologic damage with the use of NAC. Nonetheless, based on the currently available evidence, no recommendations for clinical practice can be made at this time.