The Effect of tDCS on CD-1 Mouse Behavior Post Induced Sensorimotor Cortex Injury

Author

Michelle Gardella, Graduate Center, City University of New York
Natalia Gozias, Graduate Center, City University of New York
Kristina Laktionova, Graduate Center, City University of New York
Tricia Roehrig, Graduate Center, City University of New York

Date of Degree

6-2014

Document Type

Capstone Project

Degree Name

D.P.T.

Program

Physical Therapy

Advisor

Zaghloul Ahmed

Subject Categories

Physical Therapy

Abstract

The functional topography of the motor cortex has been shown to be modifiable by transcranial direct current stimulation (tDCS). tDCS works by directing electrical currents into the brain which induces alterations in neuroplastic cortical excitability. This experiment’s aim was to test the effect of tDCS on recovery of skilled locomotion, recovery of balance, and recovery of grip strength after bilateral electrolytic lesions to sensorimotor cortices in mice. Tests employed in this experiment included the ladder test, grip test, and a balance pole test. We were able to show that 4 days of tDCS post brain injury in mice produced improvements in skilled locomotion, recovery of balance, and recovery of grip strength in mice.

Recommended Citation

Gardella, Michelle; Gozias, Natalia; Laktionova, Kristina; and Roehrig, Tricia, "The Effect of tDCS on CD-1 Mouse Behavior Post Induced Sensorimotor Cortex Injury" (2014). CUNY Academic Works.
https://academicworks.cuny.edu/gc_etds/805