Date of Degree
John J. Dennehy
Biology | Virology
bacteriophage; cystoviridae; host legacy effect; phenotypic shift; Pseudomonas; ÃŽÂ¦6
The Pseudomonas bacteriophage Φ6 has a long and well-established history as a model organism. Here we describe a set of experiments to extend this model system to concepts previously unclaimed. Chapter 1 presents a brief background of the ecology of viruses that infect microorganisms. Chapter 2 examines genetic mutations allowing for host range expansion. Chapter 3 presents a novel paired strain assay to study how a non genetic host-acquired factor affects fitness of these enveloped viruses on subsequent hosts. Chapter 4 is an extension of this system to include how the bacteria host is affected in virus-host coevolution.
Ford, Brian Elwood, "Pseudomonas Bacteriophage Phi6 as a Model for Virus Emergence" (2015). CUNY Academic Works.