Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system

Authors

Bradley A. Heller, New York University
Monica Ghidinelli, University of Buffalo
Jakob Voelkl, University of Tübingen
Steven Einheber, CUNY Hunter College
Ryan Smith, New York University
Ethan Grund, New York University
Grant Morahan, University of Western Australia
David Chandler, University of Western Australia
Luba Kalaydjieva, University of Western Australia
Filippo Giancotti, Memorial Sloan-Kettering Cancer Center
Rosalind H. King, University College London
Aniko Naray Fejes-Toth, Dartmouth College
Gerard Fejes-Toth, Dartmouth College
Maria Laura Feltri, University of Buffalo
Florian Lang, University of Tübingen
James L. Salzer, New York University

Document Type

Article

Publication Date

March 2014

Abstract

Functionally and spatially distinct PI 3-K pathways act either early to promote myelination downstream of axonal Neuregulin1 or late to inhibit myelination downstream of α6β4 integrin and Sgk1.

Comments

This work was originally published in The Journal of Cell Biology, available at doi:10.1083/jcb.201307057.