Date of Award
Master of Science (MS)
First Advisor or Mentor
The goal of this project was to perform a validation and a method development for an Agilent 7890 Gas Chromatograph connected to a Thermo iS50 Fourier Transform Infrared Spectrophotometer in order to put the instrument into functional and operational use. Both instruments are connected via an interface allowing for simultaneous analysis of a sample. A custom-made in-house library was created in order to search and compare to future unknown case samples. Reference materials were run and reviewed in order to determine which method and concentrations would provide the best infrared scans, and the sample repeatability runs were used to develop an acceptable library. Two methods were developed for the gas chromatograph. One method was used for a majority of samples, and one was developed for low boil materials. The FTIR was optimized for samples by using four scans and administering automatic atmospheric suppression to all runs. The GC-FTIR had the capability of distinguishing between three different fluorofentanyl isomers. Forty-one substances were added to the reference library.
Filus, Regina E., "Method Development and Validation of Controlled Substances on a Gas Chromatography - Fourier Transform Infrared Spectrophotometer" (2023). CUNY Academic Works.