Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China

Authors

Jianjun Wang, Minzu University of China
Ping Li, Minzu University of China
Basosai Li, Beijing University of Chinese Medicine
Zhiyong Guo, Minzu University of China
Edward J. Kennelly, CUNY Lehman College
Chunlin Long, Minzu University of China

Document Type

Article

Publication Date

5-19-2014

Abstract

Elephantopus scaber is an ethnomedicinal plant used by the Zhuang people in Southwest China to treat headaches, colds, diarrhea, hepatitis, and bronchitis. A new δ-truxinate derivative, ethyl, methyl 3,4,3′,4′-tetrahydroxy-δ-truxinate (1), was isolated from the ethyl acetate extract of the entire plant, along with 4 known compounds. The antioxidant activity of these 5 compounds was determined by ABTS radical scavenging assay. Compound 1 was also tested for its cytotoxicity effect against HepG2 by MTT assay (IC50 = 60 μM), and its potential anti-inflammatory, antibiotic, and antitumor bioactivities were predicted using target fishing method software.

Comments

This work was originally published in Evidence-based Complementary and Alternative Medicine : eCAM, available at doi:10.1155/2014/569594.

© 2014 Jianjun Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.