The two main advantages of space-based observation of extreme-energy (& 1019 eV) cosmic-rays (EECRs) over ground-based observatories are the increased field of view, and the all- sky coverage with nearly uniform systematics of an orbiting observatory. The former guarantees increased statistics, whereas the latter enables a partitioning of the sky into spherical harmonics. We have begun an investigation, using the spherical harmonic technique, of the reach of JEM- EUSO into potential anisotropies in the extreme-energy cosmic-ray sky-map. The technique is explained here, and simulations are presented. The discovery of anisotropies would help to identify the long-sought origin of EECRs.