Date of Award
Fall 8-28-2016
Document Type
Thesis
Degree Name
Master of Arts (MA)
Department
Chemistry
First Advisor
Dr. Wayne W. Harding
Second Advisor
Dr. Shenping Zhang
Academic Program Adviser
Dr. Yujia Xu
Abstract
(+)-Boldine, an aporphine alkaloid, is reported to be biologically active at various Central Nervous System(CNS) receptors. However, only a few Structure Activity Relationship(SAR) studies have been conducted using boldine’s aporphine scaffold. A library of novel analogs was synthesized from boldine to understand the effect of bisbenzylation at C2 and C9 positions on the affinity and selectivity at the serotonin receptors.
Recommended Citation
Joseph, Sujay, "Synthetic and Biological Exploration of (+)-Boldine - Identification of potential CNS receptor ligands" (2016). CUNY Academic Works.
https://academicworks.cuny.edu/hc_sas_etds/121
Included in
Medicinal Chemistry and Pharmaceutics Commons, Other Neuroscience and Neurobiology Commons, Therapeutics Commons, Toxicology Commons