Engineered Protein Polymer-Gold Nanoparticle Hybrid Materials for Small Molecule Delivery

Authors

Min Dai, New York University
JA Frezzo, New York University
E Sharma, New York University
R Chen, New York University
N Singh, New York University
C Yuvienco, New York University
E Caglar, CUNY Brooklyn College
S Xiao, CUNY Brooklyn College
A Saxena, CUNY Brooklyn College
JK Montclare, New York University

Document Type

Article

Publication Date

2-29-2016

Abstract

We have fabricated protein polymer-gold nanoparticle (P-GNP) nanocomposites that exhibit enhanced binding and delivery properties of the small hydrophobic molecule drug, curcumin, to the model breast cancer cell line, MCF-7. These hybrid biomaterials are constructed via in situ GNP templated-synthesis with genetically engineered histidine tags. The P-GNP nanocomposites exhibit enhanced small molecule loading, sustained release and increased uptake by MCF-7 cells. When compared to the proteins polymers alone, the P-GNPs demonstrate a greater than 7-fold increase in curcumin binding, a nearly 50% slower release profile and more than 2-fold increase in cellular uptake of curcumin. These results suggest that P-GNP nanocomposites serve as promising candidates for drug delivery vehicles.

Comments

This article was originally published in the Journal of Nanomedicine & Nanotechnology, available at doi:10.4172/2157-7439.1000356.

This article is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY).