Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae

Authors

Amr Al-Zain, CUNY Brooklyn College
Lea Schroeder, CUNY Brooklyn College
Alina Sheglov, CUNY Brooklyn College
Amy E. Ikui, CUNY Brooklyn CollegeFollow

Document Type

Article

Publication Date

July 2015

Abstract

DNA replication has to be tightly regulated to ensure genome integrity such that DNA replication takes place only once per cell cycle. The Cdc6 sequential phosphorylation by GSK-3 and Cdk1 creates a binding site for Cdc4 ubiquitin ligase to promote Cdc6 degradation.

Comments

This work was originally published in Molecular Biology of the Cell, available at doi:10.1091/mbc.E14-07-1213.