Publications and Research

Document Type


Publication Date

December 2002


Tryptophan synthase consists of two subunits, α and β. Two subgroups of β chain exist; the major group TrpEb_1 and the minor group, TrpEb_2. Conserved amino-acid residues of TrpEb_1 that make allosteric contact with the TrpEa subunit (the α chain) are absent in TrpEb_2. Representatives of Archaea, Bacteria and higher plants all exist that possess both TrpEb_1 and TrpEb_2. at least six lineages of the Archaea are likely to use TrpEb_2 as the functional β chain.


This work was originally published in Genome Biology, available at ttps://



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