Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials

Authors

Ankush Thakur, CUNY City College
Shawn Mishra, CUNY City College
Juan Pena, CUNY City College
Jing Zhou, CUNY Lehman College
Stephen Redenti, CUNY Lehman CollegeFollow
Robert Majeska, CUNY City CollegeFollow
Maribel Vazquez, CUNY City CollegeFollow

Document Type

Article

Publication Date

1-9-2018

Abstract

Strategies to replace retinal photoreceptors lost to damage or disease rely upon the migration of replacement cells transplanted into sub-retinal spaces. A significant obstacle to the advancement of cell transplantation for retinal repair is the limited migration of transplanted cells into host retina. In this work, we examine the adhesion and displacement responses of retinal progenitor cells on extracellular matrix substrates found in retina as well as widely used in the design and preparation of transplantable scaffolds. The data illustrate that retinal progenitor cells exhibit unique adhesive and displacement dynamics in response to poly-l-lysine, fibronectin, laminin, hyaluronic acid, and Matrigel. These findings suggest that transplantable biomaterials can be designed to improve cell integration by incorporating extracellular matrix substrates that affect the migratory behaviors of replacement cells.

Comments

This article was originally published in the Journal of Tissue Engineering, available at https://doi.org/10.1177/2041731417751286.

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License.