The present study “Understanding COVID-19 Among People of Dominican Descent in the U.S.: A Comparison of New York, New Jersey, Florida, Massachusetts, Pennsylvania, Rhode Island and Connecticut” is the first research study to examine the experience of people of Dominican origins residing in the United States (U.S.) amidst the pandemic caused by the SARS-CoV-2 virus. The current study is based on a probabilistic and representative sample of Dominicans across the seven states in which the majority—85%—of Dominicans living in the U.S. reside. The Dominican Studies Institute (CUNY-DSI) at City College and the School of Medicine, both of the City University of New York, conducted this study. These institutions brought together a team of researchers who worked on the design of the study and the parameters of the data analysis. The purpose of the study was twofold: First, to create knowledge on COVID-19 based on empirical evidence as it relates to the Dominican people and, second, to encourage the scientific community, particularly in the area of health, to study the effects of the pandemic on the different ethnic groups that make up the U.S.