Biochemistry Dissertations, The Graduate Center, CUNY | Dissertations, Theses, and Capstone Projects by Program | City University of New York (CUNY)

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Biochemistry Dissertations

As of 2014, all newly submitted Graduate Center dissertations and theses appear in Academic Works shortly after graduation. Some works are immediately available to read and download, and some become available after an embargo period set by the author. Dissertations and theses from before 2014 are generally accessible only to the CUNY community, but some authors have chosen to make theirs open access.

Dissertations from 2021 2021

Using the Marcus Inverted Region and Artificial Cofactors to Create a Charge Separated State in De Novo Designed Proteins, Eskil ME Andersen

Mechanism of Action of Dihydropteridine Reductase, Gabriela Arias De la Rosa

Development and Maintenance of the Thymic Epithelial Microenvironment, Shami Chakrabarti

The C. neoformans Cell Wall: A Scaffold for Virulence, Christine Chrissian

Design, Synthesis and Evaluation of Molecules with Selective and Poly-Pharmacological Actions at D1R, D3R and Sigma Receptors, Pierpaolo Cordone

Direct Recruitment of eIF4GI and/DAP5 to the 5' UTR of a Subset of Human mRNA Drives Their Cap-independent Translation, Solomon A. Haizel

Dissertations from 2020 2020

HuR Ubiquitination by BRCA1/BARD1 and Its Role in Controlling Gene Expression During DNA Damage Response, Gamage M. Aruggoda

Pointing the Zinc Finger on Protein Folding: Energetic Investigation into the Role of the Metal-Ion in the Metal-Induced Protein Folding of Zinc Finger Motifs, Inna Bakman-Sanchez

Transcription Initiation and Termination of Chemically Synthesized Small RNA Expression Vectors, Jose Cobo

Structural and Dynamic Features of a Transiently Assembled Complex between a Bacterial Tyrosine Kinase and Its Cognate Phosphatase, Imane Djemil

Oxytocin Receptor and MicroRNA-198/c-MET Signaling as Mechanisms of Chemoresistance in Pancreatic Cancer, Trisheena Harricharran

DNA Damage Recognition and UvrB Loading by UvrA within the Nucleotide Excision Repair Pathway, Silas Hartley

PARP1-Targeted Radiotherapies, Stephen Jannetti

Machine Learning Applications for Drug Repurposing, Hansaim Lim

Advanced Computational Methodologies to Study Binding Free Energies of Biomolecular Complexes, Rajat Kumar Pal

Mutational Analysis and Domain Characterization of the Apolipoprotein L-1 Ion Channel, Charles M. Schaub

Structural Studies of Peptide Toxins and Their Binding Properties Towards the Voltage Sensing Domain of Nav1.7, Ryan Schroder

Development of Ligand Guided Selection (LIGS) to Identify Specific DNA Aptamers Against Cell Surface Proteins, Hasan Ekrem Zumrut

Dissertations from 2019 2019

CK2 Negatively Regulates 5-HT4 Receptor Signaling in the Prefrontal Cortex and Mediates Depression-like Behaviors, Julia Castello Saval

The Determining Factors of the Self-Assembly of Collagen Mimetic Peptide, Fangfang Chen

Characterization of Immunomodulatory Microbial Factors in Medicinal Plants, Kriti Kalpana

Developing a Dissociative Nanocontainer for Peptide Drug Delivery, Michael Patrick Kelly

Minimalistic Peptide-Based Supramolecular Systems Relevant to the Chemical Origin of Life, Daniela Kroiss

Structural Studies on Calcium/calmodulin-dependent Activation of Eukaryotic Elongation Factor 2 Kinase, Kwangwoon Lee

Molecular Dynamics Simulations of Supramolecular Assemblies in Biology and Bionanotechnology, Anjela Manandhar

Green Tea Extract, Epigallocatechin Gallate, Protect Against Methamphetamine-Induced Striatal Neurotoxicity in Mice, Allen L. Pan

Solvation Thermodynamic Mapping in Computer Aided Drug Design, Steven Ramsey

Renal Specific RNAi Delivery by Fibrillar Nanoparticle Excipients, Sam Wong

Dissertations from 2018 2018

Functional Interactions of tau, Pin1, p53 and mRNA 3′ Processing Factors in Non-Neuronal Cells, Jorge E. Baquero

Phospholipase D-Dependent mTORC1 Activation by Glutamine, Elyssa Bernfeld

Information Content, Charge Transport Properties, and Computational Capacities of Proteins, Joseph Murphy Brisendine Jr.

Mechanisms Adopted by Dengue-2 Viruses to Induce Autophagy in Mammalian Cells, Sounak Ghosh Roy

Evidence for Organelle-Like Extracellular Vesicles from a Parasite of Drosophila and Their Function in Suppressing Host Immunity, Mary Heavner

Binding of Maize Necrotic Streak Virus (MNeSV) 3’ I-Shaped Structure (3’ ISS) to Eukaryotic Translation Factors (eIFs) and Implication in eIF4F Mediated Translation Initiation, Qiao Liu

Bacterial LPS at the Immune Modulating Component in Juzen-taiho-to, Diego Montenegro

Strategies Involving the Food-Derived Agent Curcumin to Eliminate Brain Cancer, Sumit Mukherjee

Mechanisms for Survival and Drug Resistance in Cancer Cells, Matthew B. Utter

Towards an Atomic Level Model of the Structure and Calmodulin Mediated Activation of eEF-2K, Nathan E. Will

Dissertations from 2017 2017

Chloride and Proton Binding in the E. coli 2Cl¯:1H+ CLC Exchanger, Catherine Chenal

Regulation of the Amyloid Precursor Protein by Prostaglandin J2, A Mediator of Inflammation: Relevance to Alzheimer’s Disease, Teneka L. Jean-Louis

Potential Modifications to Enzyme Replacement Therapy in Anderson-Fabry Disease, Mariam Meghdari

Lipid Sensing by Mammalian Target of Rapamycin, Deepak Menon

Pharmacological Antagonism and the Olfactory Code, Mihwa Na

Structural and Biochemical Studies of the DNA Replication Initiation Mechanism of the Second Chromosome of Vibrio cholerae, Natalia Orlova

Therapeutic Exploitation of Metabolic Checkpoints In Cancer Cells, Deven S. Patel

Mutagenesis of Human Alpha-Galactosidase A for the Treatment of Fabry Disease, Erin Stokes

Insight into the Interaction Between the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Adipocyte Fatty Acid-Binding Protein (A-FABP), Qian Wang

Dissertations from 2016 2016

Role of BEC-1/Beclin 1 and Autophagy Genes in C.elegans Germline Cell Proliferation, Kristina Ames

Tuning into Toxins and Channels: The Characterizations of Tv1 and a Human Cardiac Sodium Channel Voltage-Sensor Domain, Mohammed H. Bhuiyan

Metabolic Profiling of Genetically Modified Potato Periderm Tissues, Liqing Jin

Therapeutic Targets for Alzheimer's Disease: Insights from In Vitro and In Vivo Models of Inflammation, Magdalena J. Kiprowska

Circular Oligodeoxynucleotides (Coligos) as Chemically Synthesized, Promoter-Independent Small RNA Expression Vectors, Lodoe Lama

Role of hnRNP A1 in the Regulation of HDM2 Gene Expression, Heriberto Moran

The Interaction Between Eukaryotic Translation Initiation Factor eIF4G and 3’ Cap Independent Translation Element of Barley Yellow Dwarf Virus Is Affected by Multiple Initiation Factors, Pei Zhao

Messenger RNA Transport and Translation Regulated by the 3' UTRs of Dendritic mRNAs and Abnormal Alternative Splicing of Neuroligin1 in the Fmr1 KO Mouse Hippocampus, Tianhui Zhu

Dissertations from 2015 2015

The Role of ATP and Cleavage Factor Phosphorylation in pre-mRNA 3' Cleavage Reaction, Asya Khleborodova

Characterizing Migratory Signaling Pathways Of Transplantable Retinal Progenitor Cells And Photoreceptor Precursor Cells Toward Restoration Of Degenerative Retina ' A Systems Biology Approach, Uchenna John Unachukwu

Conformational Heterogeneity and Exchange within the Junction of the Human U2-U6 snRNA Complex Measured by 19F NMR Spectroscopy, Caijie Zhao

Dissertations from 2014 2014

A Role of Yeast Adhesin Amyloids in Force-Dependent Adhesion and Biofilm Formation, Cho Xiao Juan Chan

Mechanism of Phospho-alpha-Tubulin-driven Motility in Human Breast Epithelial Cells, Shatarupa De

Mechanisms of regulation of mRNA 3' processing by p53 pathway, Emral Cakmak Devany

Role of the Polyadenylation Factor CstF-50 in regulating the BRCA1/BARD1 E3 Ubiquitin (Ub) Ligase Activity, Danae Fonseca

The Role of the Striatal Neuropeptide Neurotensin in the Methamphetamine-induced Neural Injury in Mice, Qingkun Liu

Iron regulates mRNA translation initiation through RNA iron responsive element (IRE), Jia Ma

Design And Optimization Of A De Novo Protein Charge Separation Dyad, Andrew C. Mutter

Roles of Igh Intronic Enhancer Eμ in Clonal Selection at the Pre-B to Immature B Cell Transition and in the Elimination of Autoreactive B Cells, Cheng Peng

Metabolic Checkpoints in Cancer Cell Cycle, Mahesh Saqcena

Venomic Characterization of the Terebridae and Novel Terebrid Neuropeptides, Mary Elizabeth Wright

Identification and characterization of protein phopshatases regulating the Sma/Mab pathway in C. elegans, Sheng Xiong

Fabrication and Characterization of Sol-Gel Based Nanoparticles for Drug Delivery, Reeta Yadav

Mechanisms Of Deadenylation Regulation Under Different Cellular Conditions, Xiaokan Zhang

Identification and Characterization of Protein Kinase C Substrates in Human Breast Cells, Xin Zhao

Dissertations from 2013 2013

Boronic Acids as Penicillinase Inhibitors, Juan F. Barquero

Dissertations from 2011 2011

The Role of Mdm2 in Estrogen-Mediated Breast Cancer Cell Proliferation, Angelika Brekman

Dissertations from 2008 2008

Involvement of Inflammation in Tau Pathology and Mechanisms That Drive Neurodegeneration in Alzheimer's Disease, Lisette T. Arnaud

Dissertations from 2007 2007

PldB, a Putative Phospholipase D Homologue, Mediates Quorum Sensing in Dictyostelium discoideum Development, Yi Chen

Dissertations from 2006 2006

I. Comparison of Translesion Bypass of Guanine–N2 Monoadducts of Mitomycin C and Guanine-N7 Monoadducts of 2,7-diaminomitosene by T7 exo-, Klenow exo-, eta and Klenow exo+ DNA Polymerases. II. Structure-based Design, Synthesis, Structure-conformation and Structure-activity Relationships Studies of D-Phe-Pro-D-Arg-P1’-CONH2 Tetrapeptides with Inhibitory Activity for Thrombin., Cristina C. Clement

Dissertations from 1985 1985

Aspects of Mitochondrial Oxidative Metabolism, Leslie Kushner