Dissertations from 2024
Comparative Animal Mucomics, Antonio R. Cerullo
Protein-Protein Interactions in Cell Cycle Proteins: An In silico Investigation of Two Important Players, Andriele Eichner
Development of Platinum(IV)-Gold(I)-Based Anticancer Agents, Javier E. Lopez-Hernandez
Evaluating the Reliability and Accuracy of Alchemical Binding Free Energy Methods and Calculations, Fnu Sheenam
Dissertations from 2023
Structural Basis of Signal Transduction within Environmental Sensing PAS Regulated Ser/Thr Kinases, Roksana Azad
Establishing a Mouse Model of Glioblastoma (GBM) And Developing Strategies to Eliminate Cancer Cells., Juliet N.E. Baidoo-Kanneh
Changes in the Epigenetic Landscape of Oligodendrocyte Progenitor Cells with Time, David K. Dansu
Characterization of the Conformational Binding of N-methyl Mesoporphyrin IX with DNA Model Telomeric G-Quadruplex Forming Sequences, Jessica Desamero
Improving Collagen-Mimetic Fibrils to Study Fibrillogenesis and Effects of Disease-Causing Mutations on Fibrillogenesis, Faizunnahar Dewan
Metabolic Reprogramming in KRAS-driven Cancer Cells, Ahmet Hatipoglu
Leveraging Bio-Inspired Molecules for Cancer Theranostics, Douglas S. MacPherson
Engineered PLGA Nanofibers for Drug Delivery, Andrew Mancuso
Characterization of Pathological Tau Mutants, Charles J. McDonald
Leveraging Local Perturbations to Map Allosteric Networks of Phosphatases, Tamar (Skaist) Mehlman
The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer, Samantha M. Sarrett
Singlet Oxygen-Mediated Conformational Flexibility, Antioxidant, and Isomerization Studies in Chemistry and Biochemistry, Oliver Turque
Characterization and Modulation of the Emergent Material Properties of Biomolecular Condensates, Alfredo Vidal Ceballos
Targeting HIF/Coregulator Complexes in Cancer: Characterizing Fragile Fold and Inhibitor Binding Sites of ARNT, Xingjian Xu
Dissertations from 2022
Role of Metals in Human Immune System: Study of Metal-Dependent Structural Changes of S100A12 Protein, Aleksey Aleshintsev
Determining the Roles of the Oligomerization and C-terminal Domains in Mutant p53 Gain-of-Function Activities, George K. Annor
Histone Post-translational Modification Dysregulation Contributes to Toxicity in Amyotrophic Lateral Sclerosis Proteinopathy Models, Seth A. Bennett
Molecular Mechanism of Rapamycin Resistance in Cancer Cells, Sohag Chakraborty
Structural and Biochemical Investigations of the Initiation of DNA Replication in Bacteriophage Lambda and Escherichia coli, Jillian D. Chase
Mechanism of Activation and Regulation of BY-Kinases, a Unique Family of P-Loop Enzymes, Fatlum Hajredini
Prenatal Choline Supplementation During Maternal Obesity Alters Offspring Response to Western Diets, Hunter W. Korsmo
Novel Therapeutic Strategies for Alzheimer’s Disease: Targeting Toll-Like Receptor Signaling and a Multi-Target Approach, Giovanni Oliveros
Water-based Lead Generation, Brian Olson
Cdc6 is Sequentially Regulated by PP2A-Cdc55, Cdc14, and Sic1 for Origin Licensing in S. cerevisiae, Jasmin Philip
Novel Therapeutic Strategies for Alzheimer’s Disease: Prostaglandin D2 Signaling and Its Human Polymorphisms as Well as a Polypharmacological Approach, Charles H. Wallace
Role of Nuclear Lamins in Oligodendrocyte Lineage Cells, Camila Yattah
Dissertations from 2021
Using the Marcus Inverted Region and Artificial Cofactors to Create a Charge Separated State in De Novo Designed Proteins, Eskil ME Andersen
Mechanism of Action of Dihydropteridine Reductase, Gabriela Arias De la Rosa
Development and Maintenance of the Thymic Epithelial Microenvironment, Shami Chakrabarti
Machine Learning and Solvation Theory for Drug Discovery, Lieyang Chen
The C. neoformans Cell Wall: A Scaffold for Virulence, Christine Chrissian
Design, Synthesis and Evaluation of Molecules with Selective and Poly-Pharmacological Actions at D1R, D3R and Sigma Receptors, Pierpaolo Cordone
Don't Sell Them Short, There's More to Bacterial Natural Products Than Antibiotics, Alison Clare Domzalski
Dual Control of One Component Signaling: Mechanistic and Structural Insights Into EL222 Active States, Uthama Phani R. Edupuganti
Direct Recruitment of eIF4GI and/DAP5 to the 5' UTR of a Subset of Human mRNA Drives Their Cap-independent Translation, Solomon A. Haizel
The Structural and Functional Role of Photosensing in RGS-LOV Proteins, Zaynab Jaber
Synthesis and Evaluation of C-10 Nitrogenated Aporphine Alkaloids at Serotonin and Dopamine Receptors, Anupam Karki
Development of High-Throughput Methods for Screening Venom Peptides, Tanya Napolitano
Synthesis, characterization and applications of peptide-coated nanoparticles, Mina Sadat Poursharifi
Molecular Dynamics Simulations of Self-Assemblies in Nature and Nanotechnology, Phu Khanh Tang
Dissertations from 2020
HuR Ubiquitination by BRCA1/BARD1 and Its Role in Controlling Gene Expression During DNA Damage Response, Gamage M. Aruggoda
Pointing the Zinc Finger on Protein Folding: Energetic Investigation into the Role of the Metal-Ion in the Metal-Induced Protein Folding of Zinc Finger Motifs, Inna Bakman-Sanchez
Transcription Initiation and Termination of Chemically Synthesized Small RNA Expression Vectors, Jose Cobo
Oxytocin Receptor and MicroRNA-198/c-MET Signaling as Mechanisms of Chemoresistance in Pancreatic Cancer, Trisheena Harricharran
DNA Damage Recognition and UvrB Loading by UvrA within the Nucleotide Excision Repair Pathway, Silas Hartley
PARP1-Targeted Radiotherapies, Stephen Jannetti
Machine Learning Applications for Drug Repurposing, Hansaim Lim
Advanced Computational Methodologies to Study Binding Free Energies of Biomolecular Complexes, Rajat Kumar Pal
Mutational Analysis and Domain Characterization of the Apolipoprotein L-1 Ion Channel, Charles M. Schaub
Structural Studies of Peptide Toxins and Their Binding Properties Towards the Voltage Sensing Domain of Nav1.7, Ryan Schroder
Development of Ligand Guided Selection (LIGS) to Identify Specific DNA Aptamers Against Cell Surface Proteins, Hasan Ekrem Zumrut
Dissertations from 2019
CK2 Negatively Regulates 5-HT4 Receptor Signaling in the Prefrontal Cortex and Mediates Depression-like Behaviors, Julia Castello Saval
The Determining Factors of the Self-Assembly of Collagen Mimetic Peptide, Fangfang Chen
Characterization of Immunomodulatory Microbial Factors in Medicinal Plants, Kriti Kalpana
Developing a Dissociative Nanocontainer for Peptide Drug Delivery, Michael Patrick Kelly
Minimalistic Peptide-Based Supramolecular Systems Relevant to the Chemical Origin of Life, Daniela Kroiss
Structural Studies on Calcium/calmodulin-dependent Activation of Eukaryotic Elongation Factor 2 Kinase, Kwangwoon Lee
Molecular Dynamics Simulations of Supramolecular Assemblies in Biology and Bionanotechnology, Anjela Manandhar
Green Tea Extract, Epigallocatechin Gallate, Protect Against Methamphetamine-Induced Striatal Neurotoxicity in Mice, Allen L. Pan
Solvation Thermodynamic Mapping in Computer Aided Drug Design, Steven Ramsey
Renal Specific RNAi Delivery by Fibrillar Nanoparticle Excipients, Sam Wong
Dissertations from 2018
Functional Interactions of tau, Pin1, p53 and mRNA 3′ Processing Factors in Non-Neuronal Cells, Jorge E. Baquero
Phospholipase D-Dependent mTORC1 Activation by Glutamine, Elyssa Bernfeld
Information Content, Charge Transport Properties, and Computational Capacities of Proteins, Joseph Murphy Brisendine Jr.
Mechanisms Adopted by Dengue-2 Viruses to Induce Autophagy in Mammalian Cells, Sounak Ghosh Roy
Bacterial LPS at the Immune Modulating Component in Juzen-taiho-to, Diego Montenegro
Strategies Involving the Food-Derived Agent Curcumin to Eliminate Brain Cancer, Sumit Mukherjee
Mechanisms for Survival and Drug Resistance in Cancer Cells, Matthew B. Utter
Towards an Atomic Level Model of the Structure and Calmodulin Mediated Activation of eEF-2K, Nathan E. Will
Dissertations from 2017
Chloride and Proton Binding in the E. coli 2Cl¯:1H+ CLC Exchanger, Catherine Chenal
Regulation of the Amyloid Precursor Protein by Prostaglandin J2, A Mediator of Inflammation: Relevance to Alzheimer’s Disease, Teneka L. Jean-Louis
Potential Modifications to Enzyme Replacement Therapy in Anderson-Fabry Disease, Mariam Meghdari
Lipid Sensing by Mammalian Target of Rapamycin, Deepak Menon
Pharmacological Antagonism and the Olfactory Code, Mihwa Na
Structural and Biochemical Studies of the DNA Replication Initiation Mechanism of the Second Chromosome of Vibrio cholerae, Natalia Orlova
Therapeutic Exploitation of Metabolic Checkpoints In Cancer Cells, Deven S. Patel
Mutagenesis of Human Alpha-Galactosidase A for the Treatment of Fabry Disease, Erin Stokes
Dissertations from 2016
Role of BEC-1/Beclin 1 and Autophagy Genes in C.elegans Germline Cell Proliferation, Kristina Ames
Tuning into Toxins and Channels: The Characterizations of Tv1 and a Human Cardiac Sodium Channel Voltage-Sensor Domain, Mohammed H. Bhuiyan
Metabolic Profiling of Genetically Modified Potato Periderm Tissues, Liqing Jin
Therapeutic Targets for Alzheimer's Disease: Insights from In Vitro and In Vivo Models of Inflammation, Magdalena J. Kiprowska
Role of hnRNP A1 in the Regulation of HDM2 Gene Expression, Heriberto Moran
Dissertations from 2015
The Role of ATP and Cleavage Factor Phosphorylation in pre-mRNA 3' Cleavage Reaction, Asya Khleborodova
Characterizing Migratory Signaling Pathways Of Transplantable Retinal Progenitor Cells And Photoreceptor Precursor Cells Toward Restoration Of Degenerative Retina ' A Systems Biology Approach, Uchenna John Unachukwu