Nanoparticles for Applications in Specific Diagnostics and Precision Medicine

Author

Naxhije Berisha, The Graduate Center, City University of New YorkFollow

Date of Degree

2-2024

Document Type

Dissertation

Degree Name

Ph.D.

Program

Chemistry

Advisor

Rein V. Ulijn

Advisor

Daniel A. Heller

Committee Members

Hiroshi Matsui

Sharon Loverde

Chysafis Andreou

Subject Categories

Amino Acids, Peptides, and Proteins | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Bioimaging and Biomedical Optics | Biology and Biomimetic Materials | Biomaterials | Biomedical Engineering and Bioengineering | Chemical Engineering | Chemicals and Drugs | Disease Modeling | Materials Science and Engineering | Medicine and Health Sciences | Nanomedicine | Nanoscience and Nanotechnology | Oncology | Organic Chemicals | Pharmaceutics and Drug Design | Pharmacology, Toxicology and Environmental Health | Pharmacy and Pharmaceutical Sciences

Keywords

heterogeneity, precision medicine, directed discovery, nanoparticle formulations, plasmonic nanoparticles, multiplexed diagnostics

Abstract

Heterogeneity is common in the expression of cancer and treatment response. Precision medicine enables healthcare providers to tailor medical care to an individual's distinct genetic and environmental makeup. This customization has the potential to result in more efficient treatments while minimizing side effects. We believe that by studying the interface of nanotechnology and cancer medicine we can elucidate innovative solutions that address the challenges of disease heterogeneity. This includes advancements in drug delivery, formulations development, and diagnostic sensing. We highlight three studies that use nanotechnology for applications in precision medicine. In Chapter 2, we highlight design optimization of drug formulations with one particular drug, sorafenib and short aromatic peptides. In Chapter 3, we extend that analysis to a larger library of drugs and pentapeptides. In Chapter 5, we demonstrate the use of a non-invasive multiplexed SERRS nanoparticle platform to both characterize cancer heterogeneity and treatment response to an immune checkpoint blockade therapy. We hope that this work will lead to the discovery of novel nano formulations to detect and treat cancer.

Recommended Citation

Berisha, Naxhije, "Nanoparticles for Applications in Specific Diagnostics and Precision Medicine" (2024). CUNY Academic Works.
https://academicworks.cuny.edu/gc_etds/5604