Dissertations, Theses, and Capstone Projects
Date of Degree
2-2024
Document Type
Dissertation
Degree Name
Ph.D.
Program
Chemistry
Advisor
Rein V. Ulijn
Advisor
Daniel A. Heller
Committee Members
Hiroshi Matsui
Sharon Loverde
Chysafis Andreou
Subject Categories
Amino Acids, Peptides, and Proteins | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Bioimaging and Biomedical Optics | Biology and Biomimetic Materials | Biomaterials | Biomedical Engineering and Bioengineering | Chemical Engineering | Chemicals and Drugs | Disease Modeling | Materials Science and Engineering | Medicine and Health Sciences | Nanomedicine | Nanoscience and Nanotechnology | Oncology | Organic Chemicals | Pharmaceutics and Drug Design | Pharmacology, Toxicology and Environmental Health | Pharmacy and Pharmaceutical Sciences
Keywords
heterogeneity, precision medicine, directed discovery, nanoparticle formulations, plasmonic nanoparticles, multiplexed diagnostics
Abstract
Heterogeneity is common in the expression of cancer and treatment response. Precision medicine enables healthcare providers to tailor medical care to an individual's distinct genetic and environmental makeup. This customization has the potential to result in more efficient treatments while minimizing side effects. We believe that by studying the interface of nanotechnology and cancer medicine we can elucidate innovative solutions that address the challenges of disease heterogeneity. This includes advancements in drug delivery, formulations development, and diagnostic sensing. We highlight three studies that use nanotechnology for applications in precision medicine. In Chapter 2, we highlight design optimization of drug formulations with one particular drug, sorafenib and short aromatic peptides. In Chapter 3, we extend that analysis to a larger library of drugs and pentapeptides. In Chapter 5, we demonstrate the use of a non-invasive multiplexed SERRS nanoparticle platform to both characterize cancer heterogeneity and treatment response to an immune checkpoint blockade therapy. We hope that this work will lead to the discovery of novel nano formulations to detect and treat cancer.
Recommended Citation
Berisha, Naxhije, "Nanoparticles for Applications in Specific Diagnostics and Precision Medicine" (2024). CUNY Academic Works.
https://academicworks.cuny.edu/gc_etds/5604
biorender publication license chapter 1
Publication License_chapter3_scheme.pdf (256 kB)
biorender publication license chapter 3
Publication License_chapter5_scheme.pdf (130 kB)
biorender publication license chapter 5
RightsLink Printable License_Figure1.1.pdf (205 kB)
Figure1.1c
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Included in
Amino Acids, Peptides, and Proteins Commons, Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons, Bioimaging and Biomedical Optics Commons, Biology and Biomimetic Materials Commons, Biomaterials Commons, Chemical Engineering Commons, Disease Modeling Commons, Nanomedicine Commons, Nanoscience and Nanotechnology Commons, Oncology Commons, Organic Chemicals Commons, Pharmaceutics and Drug Design Commons, Pharmacology, Toxicology and Environmental Health Commons