Profiling Nucleolin Phosphorylation during DNA Damage Response and Cell Cycle Arrest

Author

• Hanjun Jeon, CUNY Graduate CenterFollow

Date of Degree

6-2026

Document Type

Doctoral Dissertation

Degree Name

Doctor of Philosophy

Program

Biology

Advisor

Anjana Saxena

Committee Members

Frida Kleiman

Xinyin Jiang

Mariana Torrente

Saurabh Agarwal

Subject Categories

Cell and Developmental Biology

Keywords

Nucleolin, Phosphorylation, DNA damage, Cell Cycle, Cancer, PTM

Abstract

This dissertation examines site-specific and global phosphorylation dynamics of nucleolin (NCL) in response to DNA damage and cell-cycle perturbations. By combining phospho-specific immunoblotting with Phos-tag SDS-PAGE analysis, distinct phosphorylation patterns were identified across experimental conditions. The results define reproducible, condition-dependent phosphorylation states of NCL and provide a framework for studying its regulation under cellular stress.

Recommended Citation

Jeon, Hanjun, "Profiling Nucleolin Phosphorylation during DNA Damage Response and Cell Cycle Arrest" (2026). CUNY Academic Works.
https://academicworks.cuny.edu/gc_etds/6779