Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity

Authors

Stefan Harmsen, Memorial Sloan Kettering Cancer Center
Matthew A. Bedics, State University of New York, Buffalo
Matthew A. Wall, CUNY Hunter College
Ruimin Huang, Memorial Sloan Kettering Cancer Center
Michael R. Detty, State University of New York, Buffalo
Moritz F. Kircher, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States

Document Type

Article

Publication Date

February 2015

Abstract

High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here, we report the design and synthesis of a group of near infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS-nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumor and disease marker detection.

Comments

This work was originally published in Nature Communications, available at doi:10.1038/ncomms7570.