Date of Award

Fall 1-5-2018

Document Type

Thesis

Degree Name

Master of Arts (MA)

Departments/Programs

Biological Sciences

First Advisor

Jill Bargonetti

Second Advisor

Diego Loayza

Academic Program Adviser

Olorunseun Ogunwobi

Abstract

The overexpression of the oncogene MDM2 is common in a variety of human cancers. MDM2 overexpression is known to increase genome instability in cells by delaying DNA double strand break repair and γH2AX levels. This study explores the knockdown of MDM2 and how it may affect DNA damage signaling.

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