Date of Award
Fall 1-5-2018
Document Type
Thesis
Degree Name
Master of Arts (MA)
Department
Biological Sciences
First Advisor
Jill Bargonetti
Second Advisor
Diego Loayza
Academic Program Adviser
Olorunseun Ogunwobi
Abstract
The overexpression of the oncogene MDM2 is common in a variety of human cancers. MDM2 overexpression is known to increase genome instability in cells by delaying DNA double strand break repair and γH2AX levels. This study explores the knockdown of MDM2 and how it may affect DNA damage signaling.
Recommended Citation
Tam, Stanley, "The role of MDM2 in DNA damage signaling" (2018). CUNY Academic Works.
https://academicworks.cuny.edu/hc_sas_etds/260