Date of Award

Fall 1-5-2018

Document Type


Degree Name

Master of Arts (MA)


Biological Sciences

First Advisor

Jill Bargonetti

Second Advisor

Diego Loayza

Academic Program Adviser

Olorunseun Ogunwobi


The overexpression of the oncogene MDM2 is common in a variety of human cancers. MDM2 overexpression is known to increase genome instability in cells by delaying DNA double strand break repair and γH2AX levels. This study explores the knockdown of MDM2 and how it may affect DNA damage signaling.



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