Date of Award

Summer 8-9-2018

Document Type

Thesis

Degree Name

Master of Arts (MA)

Departments/Programs

Biological Sciences

First Advisor

Olorunseun Ogunwobi, MD, PhD

Second Advisor

Jill Bargonetti, PhD

Academic Program Adviser

Olorunseun Ogunwobi, MD, PhD

Abstract

This study focused on the molecular relationships between PVT1 exons 4A, 4B, 9 and c-Myc in prostate cancer. Data showed significant regulatory interactions between these exons and c-Myc which is strongest between PVT1 exon 9 and c-Myc. This will likely have implications for PCa where PVT1 and c-Myc are dysregulated.

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