Date of Award

Spring 5-12-2020

Document Type

Thesis

Degree Name

Master of Arts (MA)

Departments/Programs

Biological Sciences

First Advisor

Patricia Rockwell

Second Advisor

Maria Figueiredo-Pereira

Academic Program Adviser

Patricia Rockwell

Abstract

Currently, Alzheimer’s disease (AD) has no cure. Using a rat AD model, we identified aberrantly expressed proteins during pre-pathology as potential biomarkers. The expression of certain biomarkers was reversed by diazoxide, a repurposed hypertension drug. These results suggest that drug repurposing at an early stage of AD has therapeutic potential.

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