Date of Award
Spring 4-26-2022
Document Type
Thesis
Degree Name
Master of Arts (MA)
Department
Chemistry
First Advisor
Dixie Goss
Second Advisor
Akira Kawamura
Academic Program Adviser
Yujia Xu
Abstract
Fluorescence anisotropy binding assays were used to analyze the binding of eIF4E in complex with 4E-BP1 onto the 5’ m7G cap of a subset of mRNA that are known to carry cap-independent translation. These studies suggest that 4E-BP1 increases eIF4E binding affinity to 5’cap of both FGF-9 and HIF-1𝝰.
Recommended Citation
Nawaz, Izza F., "Eukaryotic Initiation Factor 4E (eIF4E) in Complex With eIF4E Binding Protein 1 (4E-BP1) Binds With Higher Affinity to m7GpppN Cap of a Subset of Human mRNAs" (2022). CUNY Academic Works.
https://academicworks.cuny.edu/hc_sas_etds/851