Grapes Cure Cancer: My First Molecular Docking Analysis of Resveratrol Binding to Anti-Apoptotic Protein BCL-2: In Silico

Authors

Sydni Ann Kolokoltsev, CUNY New York City College of TechnologyFollow

Document Type

Poster

Publication Date

12-4-2025

Abstract

B-cell lymphoma 2 (BCL-2) is an anti-apoptotic protein frequently overexpressed in cancer, enabling tumor cells to evade programmed death. Resveratrol, a grape-derived polyphenol, has reported anticancer properties. Here we performed in silico docking of resveratrol to human BCL-2 using AutoDock Vina. The best-ranked pose exhibited a predicted binding free energy of 8.0 kcal/mol and formed at least one short hydrogen bond (~1.8 Å) with pocket residues. These results support further evaluation of resveratrol as a potential modulator of BCL-2-mediated apoptosis.

Comments

This poster, second-place winner for STEM individual projects, was presented at the 43rd Semi-Annual Dr. Janet Liou-Mark Honors & Undergraduate Research Poster Presentation, Dec. 4, 2025. Mentor: Prof. Vishwas Joshi (Chemistry).