Diagnosis of Polypoidal Choroidal Vasculopathy From Fluorescein Angiography Using Deep Learning

Authors

Yu-Yeh Tsai, National Chung Cheng University
Wei-Yang Lin, National Chung Cheng University
Shih-Jen Chen, Taipei Veterans General Hospital
Paisan Ruamviboonsuk, Rajavithi Hospital
Cheng-Ho King, National Chung Cheng University
Chia-Ling Tsai, CUNY Queens CollegeFollow

Document Type

Article

Publication Date

2-2022

Abstract

Purpose: To differentiate polypoidal choroidal vasculopathy (PCV) from choroidal neovascularization (CNV) and to determine the extent of PCV from fluorescein angiography (FA) using attention-based deep learning networks.

Methods: We build two deep learning networks for diagnosis of PCV using FA, one for detection and one for segmentation. Attention-gated convolutional neural network (AG-CNN) differentiates PCV from other types of wet age-related macular degeneration. Gradient-weighted class activation map (Grad-CAM) is generated to highlight important regions in the image for making the prediction, which offers explainability of the network. Attention-gated recurrent neural network (AG-PCVNet) for spatiotemporal prediction is applied for segmentation of PCV.

Results: AG-CNN is validated with a dataset containing 167 FA sequences of PCV and 70 FA sequences of CNV. AG-CNN achieves a classification accuracy of 82.80% at image level, and 86.21% at patient-level for PCV. Grad-CAM shows that regions contributing to decision-making have on average 21.91% agreement with pathological regions identified by experts. AG-PCVNet is validatedwith56PCV sequences from the EVEREST-I study and achieves a balanced accuracy of 81.132% and dice score of 0.54.

Conclusions: The developed software provides a means of performing detection and segmentation of PCV on FA images for the first time. This study is a promising step in changing the diagnostic procedure of PCV and therefore improving the detection rate of PCV using FA alone.

Translational Relevance: The developed deep learning system enables early diagnosis of PCV using FA to assist the physician in choosing the best treatment for optimal visual prognosis. Introduction

Comments

Originally published as: Tsai, Yu-Yeh,Wei-Yang Lin, Shih-Jen Chen, Paisan Ruamviboonsuk, Cheng-Ho King, and Chia-Ling Tsai. "Diagnosis of Polypoidal Choroidal Vasculopathy From Fluorescein Angiography Using Deep Learning." Translational Vision Science & Technology, vol. 11, no. 2, 2022, p. 6, doi: https://doi.org/10.1167

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