Dissertations and Theses

Date of Degree

9-30-2026

Document Type

Dissertation

Degree Name

Doctor of Public Health (DPH)

Department

Epidemiology and Biostatistics

Advisor(s)

Elizabeth Kelvin

Chloe Teasdale

Committee Members

Elizabeth Kelvin

Chloe Teasdale

Katarzyna Wyka

Ashly Jordan

Subject Categories

Public Health

Keywords

overdose, polysubstance, cohort analysis

Abstract

In the United States, from 1999-2023, over one million lives have been lost to the drug overdose. The overdose epidemic is currently driven by polysubstance use, meaning more than one drug. Polysubstance use-related overdose mortality has increased, with highest impacts among Black and Latino populations aged 55 years and older. With the evolving drug supply, it is important to identify the combinations of polysubstance involved in overdose deaths in order to create tailored overdose prevention interventions. It is also essential to expand surveillance to examine trends by cohorts to identify communities in need of substance use care and overdose prevention.  Using robust NYC overdose mortality surveillance data, latent class and age-period-cohort analyses were used in this dissertation aimed at elucidating drug combinations present in NYC overdose mortality, and to examine cohort effects in overdose mortality overall and by race-ethnicity.

Available for download on Friday, August 18, 2028

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