Student Theses and Dissertations
Date of Award
Spring 5-3-2021
Document Type
Thesis
Degree Name
B.A. with honors
Honors Designation
yes
Program of Study
Biology
Language
English
First Advisor
Pablo Peixoto
Abstract
Although non-essential, glycine plays an important role in major metabolic reactions and is most known for its anti-inflammatory effects. An accumulation of contemporary research has shown that glycine is able to stabilize membrane potential using glycine receptors at the cellular level and to protect mitochondrial function directly, whether it is from inflammation, heavy metal poisoning, or ischemia-induced neuroinflammation. In this research, the existence of a hypothetical mitochondrial glycine receptor is examined. Immunofluorescence imaging was used to examine the presence of the glycine receptor subunits alpha 1 and alpha 2 in both non- differentiated and differentiated neuroblastoma cell lines. The preliminary results indicated the correlation between the localization of mitochondrial fluorescence and the glycine receptor in non- differentiated cells.
Recommended Citation
Milashevich, Katsiaryna, "Mitochondrial Distribution of Glycine Receptors in Motor Neuron Cell Lines" (2021). CUNY Academic Works.
https://academicworks.cuny.edu/bb_etds/110
Included in
Biology Commons, Cell Anatomy Commons, Cell Biology Commons, Molecular and Cellular Neuroscience Commons, Molecular Biology Commons, Nervous System Diseases Commons, Neurosciences Commons, Other Neuroscience and Neurobiology Commons, Structural Biology Commons