Date of Award

Spring 5-3-2021

Document Type

Thesis

Degree Name

B.A. with honors

Honors Designation

yes

Program of Study

Biology

Language

English

First Advisor

Pablo Peixoto

Abstract

Although non-essential, glycine plays an important role in major metabolic reactions and is most known for its anti-inflammatory effects. An accumulation of contemporary research has shown that glycine is able to stabilize membrane potential using glycine receptors at the cellular level and to protect mitochondrial function directly, whether it is from inflammation, heavy metal poisoning, or ischemia-induced neuroinflammation. In this research, the existence of a hypothetical mitochondrial glycine receptor is examined. Immunofluorescence imaging was used to examine the presence of the glycine receptor subunits alpha 1 and alpha 2 in both non- differentiated and differentiated neuroblastoma cell lines. The preliminary results indicated the correlation between the localization of mitochondrial fluorescence and the glycine receptor in non- differentiated cells.

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