Date of Award

Spring 5-2-2025

Document Type

Thesis

Degree Name

Master of Arts (MA)

Department

Physics and Astronomy

First Advisor

Min Xu

Second Advisor

Ying-Chih Chen

Academic Program Adviser

Mark Hillery

Abstract

We present a regularized CycleGAN with a Dense Residual U-Net to virtually stain autofluorescence images of tissue into H&E-like images. Our method outperforms standard architectures, reduces artifacts, and achieves superior FID scores, enabling efficient, label-free, and accurate digital pathology for unpaired datasets using multi-channel fluorescence inputs.

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