Date of Award

Spring 5-1-2026

Document Type

Thesis

Degree Name

Master of Arts (MA)

Department

Chemistry

First Advisor

Dr. Wayne Harding

Second Advisor

Dr. David Mootoo

Academic Program Adviser

Dr. Yujia Xu

Abstract

D1R is a compelling therapeutic target for correcting dopaminergic imbalances. However, existing ligands exhibit suboptimal pharmacokinetic properties. As such, we synthetically explored untouched structural modifications to the phenyl benzazepine scaffold. Cannabinoid-based molecules also display potential to treat neurological maladies and cancer. We synthesized Cannabichromene derivatives and uncovered enhanced anticancer activities.

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