Design and Synthesis of Substituted N,3,3-Triphenylpropanamide and 1-Benzhydryl-N-phenylazetidine-3-carboxamide Analogs and their Biological Evaluation

Author

Michael Dorogan, CUNY Hunter CollegeFollow

Date of Award

Fall 1-6-2023

Document Type

Thesis

Degree Name

Master of Arts (MA)

Department

Chemistry

First Advisor

Wayne W. Harding

Second Advisor

David Mootoo

Academic Program Adviser

Yujia Xu

Abstract

As D₁R agonism has significant implications in the treatment of cognitive deficits, we sought to develop novel D₁R PAMs, through the derigidification of BMS D₁R PAM hit compound. While we were able to synthesize derigidified analogs of the BMS hit compound, derigidification did not produce active D₁R ligands.

Recommended Citation

Dorogan, Michael, "Design and Synthesis of Substituted N,3,3-Triphenylpropanamide and 1-Benzhydryl-N-phenylazetidine-3-carboxamide Analogs and their Biological Evaluation" (2023). CUNY Academic Works.
https://academicworks.cuny.edu/hc_sas_etds/951