Investigating the Effects of Trans-Spinal Direct Current Stimulation on The Expression of NKCC1 In Mice

Author

Pasindu Weliwaththage, The College of Staten IslandFollow

Date of Award

Spring 5-31-2018

Document Type

Thesis

Department

Physical Therapy

Language

English

First Advisor

Dr. Zaghloul Ahmed

Abstract

Trans-spinal direct current stimulation (tsDCS) is a non-invasive powerful tool demonstrated to positively affect behavior and motor function. tsDCS is a neuromodulatory technique capable of altering spinal and cortical excitability and even regain motor function after complete motor paralysis (Cortes et at, 2017). tsDCS causes immediate and long-term effects in spinal excitability (Ahmed, 2011, 2013; Ahmed and Wieraszko, 2012; Cogiamanian et al., 2011, 2012). Studies have been conducted on both healthy and injured subjects. The ultimate goal is to ameliorate the devastating effects of Spinal Cord Injury. Though researchers have been successful in improving motor function, the molecular basis of the recovery still remains unknown. Our objective for this study was to investigate the effect of tsDCS on transporter protein NKCC1 for both healthy and injured animals.

Recommended Citation

Weliwaththage, Pasindu, "Investigating the Effects of Trans-Spinal Direct Current Stimulation on The Expression of NKCC1 In Mice" (2018). CUNY Academic Works.
https://academicworks.cuny.edu/si_etds/2